Congenital neuroblastoma with in-utero metastases: A report of a rare case
Keywords:
Congenital, neuroblastoma, metastases, calcifications, postmortem biopsy, histology.Abstract
Congenital Neuroblastoma is rare and the prenatal metastatic form even rarer. We describe a neonate, a product of non-consanguineous marriage, a booked and term uneventful pregnancy till the 38th week of gestation when mother had preeclampsia and abruptio placenta and was delivered via emergency caesarean section. He was but critically ill at birth with clinical evidence of metastases to the skin, bone marrow and liver (Stage 4S). Our case, the first to be documented from our center, is the prenatal form of congenital neuroblastoma with intrauterine metastases which has a uniformly poor prognosis. Abdominal ultrasound and CT scan were suggestive with masses and intralesional calcifications and the diagnosis of congenital neuroblastoma was confirmed histologically postmortem He died seven days after admission. Our case buttresses the need for improved resources to enhance early diagnosis, a high index of suspicion and optimal care in order to improve and modify outcomes.
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