Alobar holoprosencephaly survival beyond the neonatal period and associated comorbidities.
Mots-clés :
Alobar holoprosencephaly, diagnosis, survival, comorbiditiesRésumé
Holoprosencephaly results from incomplete cleavage of the forebrain during early embryogenesis period. Types of holoprosencephaly include alobar, semi-lobar, lobar and the middle interhemispheric fusion. Holoprosencephaly has been associated with various facial dysmorphism. DeMyer’s maxim of 1964 suggests that “the face suggests the brain”, where alobar holoprosencephaly presents with most severe forms of facial dysmorphism including cyclopia, synopthalmia and proboscis and a higher risk of mortality. We report two cases of alobar holoprosencephaly confirmed by magnetic resonance imaging (MRI) of the brain, one of which atypically survived beyond neonatal period.
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