Reported cases of multisystem inflammatory syndrome in neonates in the Arab World
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Reported cases of multisystem inflammatory syndrome in neonates in the Arab WorldRésumé
In July 2021 Pawar et al. described a hyperinflammatory syndrome in eonates similar to multisystem inflammatory syndrome in children (MIS-C) due to transplacental transfer of maternal SARS-CoV-2 antibodies. Their study, conducted in Kolhapur, India (September 1, 2020 – April 30, 2021), reviewed neonates born to mothers who contracted COVID-19 during pregnancy. They distinguished MIS-N from neonatal infections acquired postnatally1. By January 2022, a case series from five hospitals in Western India reported 20 neonates diagnosed with MIS-N between October 2020 and March 20212.
A systematic review by Shaiba LA et al. identified 47 neonates meeting confirmed or suspected MIS-N criteria as of October 20213. Among them, three neonates from two Arab countries were classified as suspected MIS- N based on CDC and WHO criteria for MIS-C diagnosis: Two one-day-old females from Saudi Arabia and one 14-day-old female from Qatar4.
Références
Pawar R, Gavade V, Patil N, Mali V, Girwalkar A, Tarkasband V, Loya S, Chavan A, Nanivadekar N, Shinde R, et al. Neonatal multisystem inflammatory syndrome (MIS-N) associated with prenatal maternal SARS-CoV-2: A case series. Children. 2021: 8; 572.
More K, Aiyer S, Goti A, Parikh M, Sheikh S, Patel G, Kallem V, Soni R, Kumar P. Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series. Eur J Pediatr. 2022 ;181(5):1883-1898. doi: 10.1007/s00431-022-04377-z. Epub 2022 Jan 14.PMID: 35031848; PMCID:PMC8759431.
Shaiba LA, More K, Hadid A, Almaghrabi R, Al Marri M, Alnamnakani M, Shah P. Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review. Neonatology. 2022;119(4):405-417. doi:10.1159/000524202. Epub 2022 May 5. PMID:35512651; PMCID:PMC9148888.
Shaiba LA, Hadid A, Altirkawi KA, Bakheet HM, Alherz AM, Hussain SA, et al. Case report: neonatal multisystem inflammatory syndrome associated with SARS CoV-2 exposure in two cases from Saudi Arabia. Front Pediatr. 2021: 9;652857. doi:10.3389/fped.2021.652857
Magboul S , Hassan M, Al Amri M, Alhothy A, Almaslamani E, Ellithy K, . Refractory Multi- Inflammatory Syndrome in a Two Weeks Old Neonate with COVID-19 Treated Successfully with Intravenous Immunoglobulin, Steroids and Anakinra. J Microbiol Biotechnol. 2020; 5(4); 000176
Mascarenhas, D., Goyal, M., Haribalakrishna, A. et al. Multisystem inflammatory syndrome in neonates (MISN): a systematic review. Eur J Pediatr. (2023;182: 2283–2298 . https://doi.org/10.1007/s00431-023-04906-4
Muthiah D, Chan M, Low YW, Ramasamy SN, Amin Z, Chan-Ng PPL, Low JL and Low JM (2024) Multisystem inflammatory syndrome in neonates (MIS-N): an updated systematic review. Front. Pediatr. 2024; 12:1382133. doi: 10.3389/fped.2024.1382133
Raham TF .TB prevalence and BCG Vaccinations Correlation to Multisystem Inflammatory Syndrome in Children. J Clin Trials. 2021; 11:465.
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