Facteurs associés à la mortalité des urgences néonatales dans deux Hôpitaux de Yaounde de 2020 à 2025
Keywords:
Neonatal emergencies; mortality; CameroonAbstract
Background: Neonatal emergencies remain a leading cause of neonatal mortality in sub-Saharan Africa. This study aimed to identify factors associated with mortality among neonatal emergencies in Yaoundé.
Methods: This was a multicenter retrospective analytical study conducted from January 2020 to December 2025 in two university hospitals in Yaoundé. Neonates admitted for neonatal emergencies were included. Binary logistic regression was used to identify factors associated with death.
Results: A total of 231 neonates were included. The in-hospital mortality rate was 31.2%. Factors associated with mortality included birth weight <2000 g(ORa:2.54[1.36-3.40], p=0.001), prematurity (ORa: 1,15[1,03-2,29], p=0,004), neonatal asphyxia (ORa: 5,05 [3,17-7,16], p<0,001), neonatal infection (ORa: 4,75[2,57-11,16], p< 0,001), and respiratory distress (ORa: 1,27[1,03-7,16], p =0,002).
Conclusion: Mortality from neonatal emergencies remains high in Yaoundé. Strengthening perinatal care and neonatal emergency management is essential.
References
1. OMS. Mortalité néonatale. Organisation mondiale de la Santé. Mars 2024. https://www.who.int/fr/news-room/fact-sheets/detail/newbornmortality
2. UNICEF, WHO, World Bank, United Nations. Levels and trends in child mortality report 2018. Estimates developed by the United Nations Interagency Group for Child Mortality Estimation. New York City (NY): UNICEF ; 2019.
3. Mettre fin aux décès de nouveau-nés et aux mortinaissances évitables d’ici 2030. WHO/MCA/20.04 Organisation Mondiale de la Santé,2020.
4. Enquête Démographique de Santé du Cameroun. EDS 2018.
5. Kedy Koum D, Exhenry C, Penda CI, Nzima Nzima V, Pfister RE. Morbidité et mortalité néonatale dans un hôpital de district urbain à ressources limitées à Douala, Cameroun. Arch Pediatr. 2014;21(2):147–56. doi:10.1016/j.arcped.2013.11.014.
6. Kemeze S, Moudze B, Chiabi A, Eposse C, Kaya A, Mbangue M, et al. Profil clinique et bactériologique des infections néonatales bactériennes à l'Hôpital Laquintinie de Douala, Cameroun. Pan Afr Med J. 2016 Mar 15;23:97. French. doi:10.11604/pamj.2016.23.97.8523.PMID: 27222688; PMCID: PMC4867188.
7. Lawn JE, et al. Every Newborn Study Group. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 2014 Jul 12;384(9938):189-205. doi:10.1016/S0140-6736(14)60496-7.Epub 2014 May 19.
8. UNICEF. Levels and trends in child mortality 2023. New York: United Nations Children’s Fund; 2023.
9. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008 Jan 5;371 (9606):75-84. doi: 10.1016/S0140-6736(08)60074-4.PMID: 18177778; PMCID: PMC7134569.
10. Stevenson DK, Verter J, Fanaroff AA et al. Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage. Archives of Disease in Childhood - Fetal and Neonatal Edition 2000;83:F182-5.
11. Zeitlin J, Szamotulska K, Drewniak N, Mohangoo AD, Chalmers J, Sakkeus L, Irgens L et al .; Euro-Peristat Preterm Study Group. Preterm birth time trends in Europe: a study of 19 countries. BJOG. 2013 Oct;120(11):1356-65. doi:10.1111/1471-0528.12281. Epub 2013 May 24. PMID:23700966; PMCID: PMC4285908.
12. Yogev Y, Melamed N, Bardin R, Tenenbaum-Gavish K, Ben- Shitrit G, Ben-Haroush A. Pregnancy outcome at extremely advanced maternal age. Am J Obstet Gynecol. 2010 Dec;203(6):558.e1-7. doi:10.1016/j.ajog.2010.07.039. Epub 2010 Oct 20. PMID: 20965486.
13. WHO. Born too soon: decade of action on preterm birth. 2018. Thaddeus, S. and D. Maine. "Too far to walk: maternal mortality in context." Social Science & Medicine. 1994.38(8): 1091-1110.
14. Bogale D, Markos D. Knowledge of obstetric danger signs among childbearing-age women in Goba district, Ethiopia: a cross-sectional study. BMC Pregnancy Childbirth. 2015 Mar 29;15:77. doi:10.1186/s12884-015-0508-1.PMID:25886509; PMCID: PMC4381369.
15. World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: WHO; 2016. PMID:28079998.
16. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F220-4. doi:10.1136/adc.2002.022863.PMID:15846011; PMCID: PMC1721871.
17. Millman GC. Fanaroff and Martin's neonatal‐perinatal medicine diseases of the fetus and infant, 8th edn, Vols I and II. Arch Dis Child Fetal Neonatal Ed. 2006 Nov;91 (6): F468. PMCID: PMC2672777.
18. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update. Neonatology. 2019;115(4):432 -50. doi: 10.1159/000499361. Epub 2019 Apr 11. PMID:30974433; PMCID: PMC6604659.
19. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017 Oct 14;390(10104):1770 -80. doi: 10.1016/S0140-6736 (17)31002-4. Epub 2017 Apr 20. PMID: 28434651.
20. UNICEF. Neonatal mortality estimates. New York: United Nations Children’s Fund; 2022. World Health Organization. Guidelines on basic newborn resuscitation. Geneva: WHO; 2012. ISBN: 9789241503693.
21. Ezeh OK, Agho KE, Dibley MJ, Hall J, Page AN. Determinants of neonatal mortality in Nigeria: evidence from the 2008 demographic and health survey. BMC Public Health. 2014 May 29;14:521. doi:10.1186/1471-2458-14-521.PMID:24886517; PMCID: PMC4049428.
22. Koum DC, Essomba NE, Ngaba GP, Sintat S, Ndombo PK, Coppieters Y. Morbidité et facteurs de risque de mortalité néonatale dans un hôpital de référence de Douala [Morbidity and risk factors for neonatal mortality in Douala Referral Hospital]. Pan Afr Med J. 2015 Mar 17;20:258. French. doi:10.11604/pamj.2015.20.258.5648. PMID: 26161181; PMCID:PMC4484331.
23. Bhutta ZA, Das JK, Bahl R, Lawn JE, Salam RA, Paul VK et al. Lancet Newborn Interventions Review Group; Lancet Every Newborn Study Group. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet. 2014 Jul 26;384(9940):347-70. doi: 10.1016/S0140-6736(14) 60792-3. Epub 2014 May 19.
24. Liu L, Oza S, Hogan D, Hu Y, Perin J, Zhu J et al. Global, regional, and national causes of under-5 mortality in 2000- 15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016 Dec17;388(10063):3027-35. doi:10.1016/S0140-6736(16)31593-8. Epub 2016 Nov 11.
25. Edmond KM, Kortsalioudaki C, Scott S, Schrag SJ, Zaidi AK, Cousens S et al. Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis. Lancet. 2012 Feb 11;379(9815):547- 56. doi:10.1016/S0140-6736(11)61651-6. Epub 2012 Jan 4. PMID:22226047.
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