A multi disciplinary partnership to combat neonatal sepsis deaths in Sub-Saharan Africa
Keywords:
Multi disciplinary partnership to combat neonatal sepsis deaths in Sub-Saharan AfricaAbstract
Neonatal sepsis is a global issue and a leading cause of death in the first 28 days of life1,2especially in low- and middle-income countries (LMIC) where 98% of neonatal deaths occur.3Despite the extremely high burden of neonatal sepsis and associated deaths, data on the causative pathogens, antibiotic resistance profile, and infection impact is lacking from many LMIC.4-6As recently as 2019, not a single African country had published population-level data on neonatal sepsis. The reasons for this include limited access to microbiology laboratories,
poor healthcare infrastructure, and challenges in health care data management.
References
Oza S, Lawn JE, Hogan DR, Mathers C, Cousens SN. Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000–2013. Bull World Health Organ. 2015;93(1):19-28. doi:10.2471/BLT.14.139790
Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. The Lancet. 2016;388(10063):3027-3035. doi:10.1016/S0140-6736(16)31593-8
Lawn JE, Blencowe H, Oza S, et al. Every Newborn: progress, priorities, and potential beyond survival. The Lancet.2014;384(9938):189-205. doi:10.1016/S0140-6736(14)60496-7
Målqvist M, Eriksson L, Nga NT, et al. Unreported births and deaths, a severe obstacle for improved neonatal survival in low-income countries; a population based study. BMC Int Health Hum Rights. 2008;8(1):4.doi:10.1186/1472-698X-8-4
Traoré FB, Sidibé CS, Diallo EHM, et al. Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis. Front Public Health. 2024;12. doi:10.3389/fpubh.2024.1272193
Chaurasia S, Sivanandan S, Agarwal R, Ellis S, Sharland M, Sankar MJ. Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance. BMJ. 2019;364:k5314.
Fleischmann C, Reichert F, Cassini A, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child. 2021;106(8):745-752. doi:10.1136/archdischild-2020-320217
Kontou A, Kourti M, Iosifidis E, Sarafidis K, Roilides E. Use of Newer and Repurposed Antibiotics against Gram-Negative Bacteria in Neonates. Antibiotics. 2023;12(6):1072. doi:10.3390/antibiotics12061072
Iroh Tam PY, Musicha P, Kawaza K, et al. Emerging Resistance to Empiric Antimicrobial Regimens for Pediatric Bloodstream Infections in Malawi (1998–2017). Clin Infect Dis. 2019;69(1):61-68. doi:10.1093/cid/ciy834
Patel TS, Sati H, Lessa FC, et al. Defining access without excess: expanding appropriate use of antibiotics targeting multidrug-resistant organisms. Lancet Microbe. 2024;5(1):e93-e98. doi:10.1016/S2666-5247(23)00256-2
Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. The Lancet. 2016;387(10014):168-175. doi:10.1016/S0140-6736(15)00474-2
Downloads
Published
Issue
Section
License
Copyright (c) 2024 JOURNAL OF AFRICAN NEONATOLOGY
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This is an open-access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.